Medicine

Ascofuranone is an antibiotic produced by the fungus Ascochyta visiae[1] that inhibits the Trypanosoma brucei alternative oxidase and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of sleeping sickness.[2] The compound is effective both in vitro cell culture and in infections in mice.[1] Ascofuranone has also been reported to have an

An iodide ion is an iodine atom with a −1 charge.[1] Compounds with iodine in formal oxidation state −1 are called iodides. This can include ionic compounds such as caesium iodide or covalent compounds such as phosphorus triiodide. This is the same naming scheme as is seen with chlorides and bromides. The chemical test for an iodide compound is to acidify the aqueous compound by adding some drops of acid, to dispel any carbonate ions present, then adding lead(II) nitrate, yielding a bright yellow precipitate of lead iodide. Most ionic iodides are soluble, with the exception of yellow silver iodide

An additional electrode (usually green) is present in modern four-lead and twelve-lead ECGs. This is the ground lead and is placed on the right leg by convention, although in theory it can be placed anywhere on the body. With a three-lead ECG, when one dipole is viewed, the remaining lead becomes the ground lead by default.

Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis. Because both of these arsenicals carried considerable risk of side-effects, they were replaced for this indication by penicillin in the 1940s. Both salvarsan and neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications.[1] This scheme is the basis for most modern pharmaceutical research. Both

A compound analgesic is an analgesic with more than one active ingredient. This includes many of the stronger prescription analgesics. Common active ingredients used in compound analgesics include: aspirin paracetemol (acetaminophen) codeine or oxycodone phenacetin Once readily available over the counter and in supermarkets, compound analgesics became associated with substance abuse and are now more restricted in many countries. As a result, some once famous brands such as APC and Bex have either disappeared, or have become brands of simple analgesics.

If abnormally prolonged or shortened, there is a risk of developing ventricular arrhythmias. prefferably 3 consequtive reading sof qt are take mainly in lead 2 or long lead. and then mean is calulated. if lead 2 is not suitabal then leads in sequence of V5 V4 V3 V2 are selected.

Tin(IV) iodide, also known as stannic iodide is the chemical compound with the formula SnI4. This tetrahedral molecule crystallises as a bright orange solid that dissolves readily in nonpolar solvents such as benzene.[2] The compound is usually prepared by the reaction of iodine and tin:[3] Sn + 2 I2 → SnI4 The compound hydrolyses in water. In aqueous hydroiodic acid, it reacts to form a rare example of a metal hexaiodide:[3] SnI4 + 2 I− → [SnI6]2−

Lead (II) iodide (PbI2) is a toxic, yellowish solid. It displays a range of colors with varying temperature from bright yellow at room temperature to brick red. On cooling, its color returns to yellow. In its crystalline form it is used as a detector material for high energy photons including x-rays and gamma rays. It is also known as plumbous iodide, derived from the Latin name for lead plumbum. Lead iodide is toxic due to its lead content. In the nineteenth century it was used as an artists' pigment under the name Iodine Yellow, but it was too unstable to be useful.[2] Lead

Nepetalactone is an organic compound first isolated in the plant catnip, Nepeta cataria. Nepetalactone is bicyclic terpenoid, i.e. it is a ten-carbon compound derived from isoprene with two fused rings, a cyclopentane and a lactone. Nepetalactone is a cat attractant. The structure and the effects of the compound are similar to those of valepotriates. A number of isomers of nepetalactone are known. Nepetalactone was first reported in 1941 after it was isolated by steam distillation of catnip.[1]

SB-271,046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271,046 through a structure-activity relationship (SAR) study.[1] SB-271,046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood-brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.[2] SB-271,046

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