Side effects of Tizanidine
Tizanidine use occasionally causes drug induced liver injury. In controlled clinical studies, approximately 5% of patients treated with Zanaflex had elevations of liver function tests (ALT, AST) to greater than 3 times the upper limit of normal (or 2 times if baseline levels were elevated).[citation needed]
Tizanidine use has been associated with hallucinations. Visual hallucinations and delusions have been reported in 5 of 170 patients (3%) in two North American controlled clinical studies.[citation needed]
If therapy needs to be discontinued, especially in patients who have been receiving high doses for long periods, the dose should be decreased slowly to minimize the risk of withdrawal and rebound hypertension, tachycardia, and hypertonia.
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Tizanidine is available in tablets with "cor 138" on one side and 2 scores on the back that create an X, or R179 on one side and a single score through the middle of the back, or a white oval pill with R180 on one side and 2 scores on the back that create an X. It is also found as a circular white pill with the number 503 on one side and X-scored on the back[2].
Tizanidine is supplied as 2 and 4 mg tablets for oral administration, and in gel cap form in doses of 2 mg, 4 mg,
Concomitant use of tizanidine and moderate or potent CYP1A2 inhibitors is contraindicated. Concomitant use of tizanidine with fluvoxamine, a potent CYP1A2 inhibitor in man, resulted in a 33-fold increase in the tizanidine AUC (plasma drug concentration-time curve) by fluvoxamine.
Tizanidine (brandnames Zanaflex, Sirdalud) is a drug which is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia[1].
Tizanidine may cause hypotension, so caution is advised when it is used in patients who have a history of
Radiation therapy is in itself painless. Many low-dose palliative treatments (for example, radiotherapy to bony metastases) cause minimal or no side effects, although short-term pain flare up can be experienced in the days following treatment due to oedema compressing nerves in the treated area. Treatment to higher doses causes varying side effects during treatment (acute side effects), in the months or years following treatment (long-term side effects), or after re-treatment (cumulative side effects). The nature, severity, and longevity of side effects depends on the organs that receive the radiation, the treatment itself (type of radiation, dose, fractionation, concurrent chemotherapy), and
Side effects of prazepam are less profound than with other benzodiazepines.[7] Excessive drowsiness and with longer term use drug dependence are the most common side effects of prazepam.[8][9] Side effects such as fatigue or "feeling spacey" can also occur but less commonly than with other benzodiazepines. Other side effects include feebleness, clumsiness, lethargic, clouded thinking and mentally slowness.[10][11][12]
Side effects of prazepam are less profound than with other benzodiazepines.[7] Excessive drowsiness and with longer term use drug dependence are the most common side effects of prazepam.[8][9] Side effects such as fatigue or "feeling spacey" can also occur but less commonly than with other benzodiazepines. Other side effects include feebleness, clumsiness, lethargic, clouded thinking and mentally slowness.
Side effects (for the women's formulas) may include temporary burning/irritation of the vaginal area, moderate drowsiness, and headache similar to a sinus headache, and hives. Personal Product's 1-Day brand literature also includes upper respiratory infection in its list of side effects. These side effects may be only temporary, and do not interfere with the patient's comfort enough to outweigh the end result.
The most significant side-effects of loxapine are excessive salivation and indifference to surroundings. Loxapine, if administered to individuals without schizophrenia, causes emotional quieting and insensitivity. In persons with psychosis, it may control aggressive behaviour and restlessness, and reduce the severity of hallucinations and delusions. Other Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor, gynecomastia and sedation.
Common side effects include:
Low blood pressure (11% of patients)
Headache
Nausea
Slow heart rate
More rare side effects include:
Confusion
Paresthesia
Somnolence
Tremors
Side effects for any drug are difficult to predict, but commonly reported side effects for Fioricet include:
Dizziness
Drowsiness
Intoxicated feeling
Light-headedness
Nausea
Vomiting
Sedation
Addiction
Shortness of breath
Abdominal pain
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