Concomitant use of tizanidine and moderate or potent CYP1A2 inhibitors is contraindicated. Concomitant use of tizanidine with fluvoxamine, a potent CYP1A2 inhibitor in man, resulted in a 33-fold increase in the tizanidine AUC (plasma drug concentration-time curve) by fluvoxamine.
Tags: Medicine stubs, Pharmacology stubs
Tizanidine is available in tablets with "cor 138" on one side and 2 scores on the back that create an X, or R179 on one side and a single score through the middle of the back, or a white oval pill with R180 on one side and 2 scores on the back that create an X. It is also found as a circular white pill with the number 503 on one side and X-scored on the back[2]. Tizanidine is supplied as 2 and 4 mg tablets for oral administration, and in gel cap form in doses of 2 mg, 4 mg,
Tizanidine (brandnames Zanaflex, Sirdalud) is a drug which is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia[1]. Tizanidine may cause hypotension, so caution is advised when it is used in patients who have a history of
Tizanidine use occasionally causes drug induced liver injury. In controlled clinical studies, approximately 5% of patients treated with Zanaflex had elevations of liver function tests (ALT, AST) to greater than 3 times the upper limit of normal (or 2 times if baseline levels were elevated).[citation needed] Tizanidine use has been associated with hallucinations. Visual hallucinations and delusions have been reported in 5 of 170 patients (3%) in two North American controlled clinical studies.[citation needed] If therapy needs to be discontinued, especially in patients who have been receiving high doses for long periods, the dose should be decreased slowly to minimize the risk
Glycoconjugates is the general classification for carbohydrates covalently linked with other chemical species.[1] Glycoconjugates are very important compounds in biology and consist of many different categories such as glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. They are involved in cell-cell interactions, including cell-cell recognition, and cell-matrix interactions.
Adverse effects, contraindications and interactions are similar to other beta blockers.
The following agents are also listed as agonists by MeSH.[4] amidephrine amitraz anisodamine apraclonidine brimonidine cirazoline detomidine dexmedetomidine epinephrine ergotamine etilefrine indanidine lofexidine medetomidine mephentermine metaraminol methoxamine midodrine mivazerol naphazoline norepinephrine norfenefrine octopamine oxymetazoline phenylpropanolamine rilmenidine romifidine synephrine talipexole tizanidine
Linezolid is a weak monoamine oxidase inhibitor (MAOI), and should not be used concomitantly with other MAOIs, tyramine-rich foods (such as pork, aged cheeses, alcoholic beverages, or smoked and pickled foods), or serotonergic drugs; there have been postmarketing reports of serotonin syndrome when linezolid was given with or soon after discontinuing serotonergic drugs, particularly selective serotonin reuptake inhibitors such as paroxetine and sertraline.[9][85][86] It may also enhance the blood pressure-increasing effects of sympathomimetic drugs such as pseudoephedrine or phenylpropanolamine.[5][87] Linezolid does not inhibit or induce the cytochrome P450 system, and therefore does not have any CYP450-related interactions.[1]
Pharmacy practice is the discipline of pharmacy which involves developing the professional roles of pharmacists. Areas of pharmacy practice include: Disease-state management Clinical interventions (refusal to dispense a drug, recommendation to change and/or add a drug to a patient's pharmacotherapy, dosage adjustments, etc.) Professional development. Pharmaceutical care Extemporaneous pharmaceutical compounding. Communication skills Health psychology. Patient care Drug abuse prevention Prevention of drug interactions, including drug-drug interactions or drug-food interactions Prevention (or minimization) of adverse events Incompatibility Drug discovery and evaluation Community Pharmacy Detect pharmacotherapy-related problems, such as: The patient is taking a drug which he/she does not need. The patient is taking a drug for a specific disease, other than one afflicting the patient. The patient needs a
False elevation in free and total serum T 3 as measured by Amerlex-M kit
Anticoagulants, Sulphonylureas, Diuretics/ACE inhibitors/Digoxin, Lithium, Methotrexate/Cyclosporin, Cimetidine